Continuous Processing Technologies
ADVANCED CRYSTALLISATION TECHNIQUES
Oscillary Baffled Reactors & Crystallisers
ADVANCED CRYSTALLISATION TECHNIQUES
Our continuous Oscillatory baffled reactors (OBR) Crystallisers are effective for reactions ,work ups and crystallisations. They provide high intensity, low shear mixing with great temperature control due to the high jacket area to process volume ratio.
REACTORS
We provide a range of fully automated reactors:
Single vessel batch or continuous stirred tank reactors and multi-vessel continuous or semi-continuous chained stirred tank reactors in various sizes.
Liquid/Liquid, Solid/Liquid and Gas/Liquid capabilities at pressures up to 25 bar and temperatures up to 200 °C
Improved residence time distribution compared to traditional stirred tanks
CRYSTALLISERS
Ideal for cooling, evaporative and antisolvent crystallisations
Low shear mixing produces little particle attrition with good control over particle size distribution and morphology
Flexible modes of operation – batch, semi- or fully continuous
KEY FEATURES
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Unique chemistry facilitators for gas to liquid hydrogenency
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Liquid liquid, gas liquid and solid liquid reactions and crystallisations acting as a catalyst for crystallisation
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Highly efficient heat transfer and mixing capabilities
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Excellent crystal size and morphology control
Available in a range of sizes to suit your requirements from Laboratory to production scales.
Can be provided with temperature controlled transfer lines to avoid unwanted crystallisations or side reactions.
Probe adapters available to suit most PAT
Continous Filtration
& Drying
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DISTINCT ADVANTAGES OVER BATCH PROCESSING
Designed by us at AWL, these unique internationally patented Continuous Filtration or 'Flow Chemistry') systems are at the cutting edge of modern chemistry technology. They are designed to enhance your key protocols and efficiencies in Fine Chemical, Pharmaceutical and Laboratory processing.
The AWL Continuous Filter Dryer systems automatically filter, wash, dry and discharge solids in a continuous manner. The versatility of Continuous Filtration's ability to continually loop process smaller amounts of APIs in 3 to 4 minutes from slurry to dry cake with precise repeatability, yet still being able to produce larger quantity production scale throughput - makes it highly suitable for both APIs & HPAPIs. Continuous Filtration is a contained, safe and highly controlled way to process hazardous or valuable ingredients or HPAPIs highly potent active pharmaceutical ingredients.
PROTOCOLS
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No mechanical agitation damage or crystal shear
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Reliable consistency in cake filtration
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Accurate repeatability of washing parameters
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Atomisation nozzles dispense wash solvent preventing disturbance to the cake
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Thinner cake height technology, typically 10 - 30 mm
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Improved wash efficiency!
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Local HMI or DCS control system allows for safe operation
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Integrated alarm systems for automated continuous operation
KEY FEATURES
Lower footprint - A complete plant, replacing a traditional 2 to 3 floor batch production facility!
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Very high repeatability and consistency in filtration
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Reduced solvent usage, energy and waste
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0.1 mm heel! Significantly lower heel – Significantly reducing product loss!
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Entry to exit cycle time in minutes… not hours!
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Filtration, washing and drying in just a few short runs!
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Drying to <1% moisture content achieved within minutes
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Typical throughputs of 1kg per hour to 24kg per hour of dried product
VALIDATEABLE TECHNOLOGY
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Successful industrial product trials carried out with both UK Pharma and Fine Chemical
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Multiple academic papers published using the AWL continuous filter dryer
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Drying validated with drying kinetics model
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Credible technology due to detailed independent empirical research
Our Continuous Filtration is Available in Evaluation, Pilot, Production and Commercial Scale platforms. Typically from 1kg per hour to 24kg per hour of dried product.